Search on: PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY 
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Descriptor English:   Leukoencephalopathy, Progressive Multifocal 
Descriptor Spanish:   Leucoencefalopatía Multifocal Progresiva 
Descriptor Portuguese:   Leucoencefalopatia Multifocal Progressiva 
Synonyms English:   Encephalitis, JC Polyomavirus
Progressive Multifocal Leukoencephalopathy  
Tree Number:   C02.182.525.500
C02.256.721.500
C02.290.575
C02.839.550
C10.228.140.430.520.750.500
C10.228.140.695.750
C10.228.228.245.340.500
C10.228.228.399.750.500
C10.314.450
Definition English:   An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7) 
History Note English:   1973(1971) 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DH diet therapy
DT drug therapy EC economics
EM embryology EN enzymology
EP epidemiology EH ethnology
ET etiology GE genetics
HI history IM immunology
ME metabolism MI microbiology
MO mortality NU nursing
PS parasitology PA pathology
PP physiopathology PC prevention & control
PX psychology RA radiography
RI radionuclide imaging RT radiotherapy
RH rehabilitation SU surgery
TH therapy TM transmission
US ultrasonography UR urine
VE veterinary VI virology
Record Number:   29437 
Unique Identifier:   D007968 

Occurrence in VHL: 		 

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